- 100% NATURAL PRODUCT: No artificial colors or flavors
- Verified herb identity, confirmed highest quality of raw herb and the extract
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- Third-party lab tested, pure Honokiol.
Honokiol, a biologically active substance extracted from Magnolia officinalis, which is widely used in traditional Chinese medicine, has been shown to exert significant anti-inflammatory effects and improve depression-like behavior caused by inflammation.
Keywords: Magnolia officinalis; antioxidant; honokiol; neuroinflammation; neuropathic pain.
Honokiol ameliorated LPS-induced NF-κB activation in the hippocampus and significantly reduced the levels of the pro-inflammatory cytokines; tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), and interferon γ (IFN-γ). In addition, honokiol inhibited LPS-induced indoleamine 2,3-dioxygenase (IDO) activation and quinolinic acid (a toxic product) increase and reduced the level of free calcium in brain tissue, thereby inhibiting calcium overload.
* The statements in this section have not been evaluated by the FDA or EFSA.
References
1. Borgonetti V, Galeotti N. Honokiol-Rich Magnolia officinalis Bark Extract Attenuates Trauma-Induced Neuropathic Pain. Antioxidants (Basel). 2023 Jul 28;12(8):1518. doi: 10.3390/antiox12081518. PMID: 37627513; PMCID: PMC10451803.
2. Zhang B, Wang PP, Hu KL, et al. Antidepressant-Like Effect and Mechanism of Action of Honokiol on the Mouse Lipopolysaccharide (LPS) Depression Model. Molecules. 2019;24(11):2035. Published 2019 May 28. doi:10.3390/molecules24112035
3. Borgonetti V, Galeotti N. Honokiol-Rich
Magnolia officinalis Bark Extract Attenuates Trauma-Induced Neuropathic Pain. Antioxidants (Basel). 2023 Jul 28;12(8):1518. doi: 10.3390/antiox12081518. PMID: 37627513; PMCID: PMC10451803.
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