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Salvia miltiorrhiza extract, also known as Dan shen extract or red sage extract, is derived from the dry root of salvia miltiorrhiza. Main active ingredients of Dan Shen Extract are Salvianic Acid B, Tanshinol, Tanshinone IIA, Salianic Acid A and Danshensu. Salvia miltiorrhiza extract can possibly regulate blood sugar and bood fat, improve blood circulation, and protect heart muscles and liver cells. It may also have antimicrobial and anti-inflammatory effects. Salvia miltiorrhiza extract is mainly used in dietary supplements, health drinks and cosmetics.
Danshen (Salvia miltiorrhiza) is an important Traditional Chinese Medicine (TCM) with a range of reported effects, primarily linked to its cardiovascular and cerebrovascular actions.
Here's a breakdown of the effects of Danshen extract:
1. Cardiovascular and cerebrovascular health
- Improved Blood Circulation: Danshen is believed to thin the blood by inhibiting platelet aggregation and widening blood vessels, potentially enhancing circulation. It has been traditionally used to treat problems with circulation, including those affecting the brain and heart.
- Heart Protection: Research suggests that Danshen and its components, particularly tanshinone IIa, may protect against heart conditions like atherosclerosis, myocardial infarction, ischemia/reperfusion injury, arrhythmia, cardiac hypertrophy, and fibrosis.
- Stroke Prevention and Treatment: Danshen may help in the prevention and treatment of cerebral infarction (stroke) through its anti-atherosclerotic, anti-hypertensive, anti-platelet aggregation, anti-inflammatory, and anti-oxidative properties.
2. Other reported effects
- Anti-Inflammatory Effects: Danshen has been shown to possess anti-inflammatory properties, potentially beneficial in conditions like allergic asthma and rheumatoid arthritis.
- Antioxidant Effects: The extract exhibits antioxidant activity, scavenging free radicals and potentially protecting against oxidative stress in various diseases.
- Anti-Diabetic Effects: Studies indicate Danshen may be helpful in managing diabetes by improving in sulin sensitivity and potentially preventing complications like diabetic retinopathy.
- Potential Anti-Cancer Effects: Some research suggests Danshen may have anti-cancer properties, inhibiting the proliferation of various cancer cell lines and potentially circumventing drug resistance in oral cancer cells. However, it is mostly considered an adjunct therapy.
- Neuroprotective Effects: Danshen may offer protection against neurological disorders like subarachnoid hemorrhage and spinal cord injury through its antioxidative and neuroprotective properties.
3. Important considerations
- Interactions with Other Medications: Danshen may interact with medications such as Warfarin (increasing the risk of bleeding) and Digoxin (interfering with laboratory measurements). It is important to consult with a healthcare professional before taking Danshen, especially if you are on other medications.
- Potential Side Effects: Possible side effects include itching, upset stomach, drowsiness, and a potential risk of bleeding, especially at high doses.
- Clinical Trial Limitations: While many studies suggest beneficial effects, the quality of clinical trials has sometimes been questioned, making it difficult to draw definitive conclusions about its efficacy in certain areas.
- Pregnancy and Breastfeeding: There is insufficient information regarding the safety of Danshen during pregnancy and breastfeeding, so it is best to avoid use during these periods.
| In conclusion, Danshen extract offers a variety of potential health benefits, particularly in the cardiovascular system, but it's important to be aware of potential side effects and interactions, and to consult with a healthcare professional before use. |
* The statements in this section have not been evaluated by the FDA or EFSA.
References
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