| Customization: | Available |
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| Certification: | ISO |
| Assay Method: | HPLC-MS, HPLC |
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Valerian is rich in phytochemicals, such as phenolic compounds, which are related to antioxidant activity. More than 150 different phytochemical compounds have been identified in valerian root, with the main components being sesquiterpenes (e.g., valerenic acid), iridoids, and flavonoids etc. |
Valeric acid is also known as pentanoic acid (C5H10O2). It is a major active chemical ingredient of valerian, a plant native to North America, Europe, and Asia. The dried root of valerian has been used to treat insomnia, depression, and anxiety since ancient times. |
Valeric acid is one of the many energy sources of intestinal microbiota, making them crucial to gastrointestinal (GI) health. Valeric acid exerts strong GI protective effects. A study involving mice that received high doses of radiation showed that valeric acid supplementation increased the survival rate of irradiated mice, improved GI health, and enhanced tissue integrity.
Valeric acid can also modulate brain function; it was recently shown to play a role in the initiation and progression of Alzheimer's disease (AD). Multiple studies have reported alterations in the gut microbiome composition of AD patients compared to healthy individuals. One potential mechanism is through the production of SCFAs in the gut. A study showed that valeric acid and acetic acid, two SCFAs, increased the expression of pro-inflammatory cytokines and endothelial damage in the brain. An increase in these two SCFAs compromised the integrity of the blood-tissue barrier, caused low-grade systemic inflammation, and facilitated the AD pathological cascade.3 Therefore, interventions that modulate the gut microbiome and promote beneficial bacteria and bacterial metabolites may be useful in preventing, slowing down, or ameliorating neurodegeneration in AD.
* The statements in this section have not been evaluated by the FDA or EFSA.
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