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Lignans are a group of phytonutrients which are widely distributed in the plant kingdom. Flaxseed is the richest source of providing lignan precursor such as secoisolariciresinol diglucoside (SDG). Which has been reported to remarkably suppress inflammation and oxidative stress, may have potential therapeutic value in OA.
SDG treatment downregulated the expression of pro-inflammatory factors induced by IL-1β in vitro, in vivo, SDG has been identified to have chondroprotective effects in DMM-induced and collagen-induced arthritis models
According to the recent study prepared by the American Institute for Cancer Research (AICR), an adequate intake of dietary fiber contributes to reducing the risk of colorectal cancer. In addition, the flaxseed and the oil extracted from it are considered to be food products with a high content of anti-inflammatory, unsaturated α-linolenic acid (ALA). However, the authors of the most recent scientific research have assigned the anticancer significance of flax seeds to plant lignan - secoisolariciresinol diglycoside (SDG), of which flaxseed is the main food source.
Keywords: Extracellular matrix; Inflammation; NF-κB pathway; Nrf2/HO-1 pathway; Osteoarthritis; Secoisolariciresinol diglucoside; Antioxidant; flaxseed oil; metabolic syndrome; oxidative stress; dietary supplementation; flax seeds.
Secoisolariciresinol diglucoside (SDG) is a lignan found in flaxseed that has many potential health benefits, including:
- Anti-inflammatory and antioxidant: SDG can reduce inflammation and oxidative stress.
- Blood sugar and blood fat lowering: SDG can lower blood sugar and blood fat levels.
- Obesity and metabolic disease: SDG can help with obesity and metabolic diseases by reducing body and tissue weight, and increasing adiponectin levels.
- Osteoarthritis: SDG can suppress inflammation and extracellular matrix degradation in osteoarthritis.
- Cancer risk: SDG may reduce cancer risk by preventing pre-cancerous cellular changes.
- Cardiovascular disease: SDG may protect against cardiovascular disease by lowering blood pressure and reducing lipid and glucose concentrations.
Secoisolariciresinol diglucoside (SDG), is the main lignan in wholegrain flaxseed, known for its beneficial effects including anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-obesity, hypolipidemic, and neuroprotective effects.
* The statements in this section have not been evaluated by the FDA or EFSA.
References
1. Dobrowolska, K., & Regulska-Ilow, B. (2021). The legitimacy of using dietary supplement diglycoside secoisolariciresinol (SDG) from flaxseed in cancer. Roczniki Panstwowego Zakladu Higieny, 72(1), 9-20. 10.32394/rpzh.2021.0144
2. Zhang Z, Wang S, Liu X, et al. Secoisolariciresinol diglucoside Ameliorates Osteoarthritis via Nuclear factor-erythroid 2-related factor-2/ nuclear factor kappa B Pathway: In vitro and in vivo experiments. Biomed Pharmacother. 2023;164:114964. doi:10.1016/j.biopha.2023.114964
3. Imran, M., Ahmad, N., Anjum, F. M., Khan, M. K., Mushtaq, Z., Nadeem, M., & Hussain, S. (2015). Potential protective properties of flax lignan secoisolariciresinol diglucoside. Nutrition journal, 14, 71. 10.1186/s12937-015-0059-3
4. Imran, M., Ahmad, N., Anjum, F. M., Khan, M. K., Mushtaq, Z., Nadeem, M., & Hussain, S. (2015). Potential protective properties of flax lignan secoisolariciresinol diglucoside. Nutrition journal, 14, 71. 10.1186/s12937-015-0059-3
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