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- Third-party lab tested, pure Honokiol.
- May suooprt clam moods, nerve function, cortisol balance, and immune function
Honokiol, a biologically active substance extracted from Magnolia officinalis, which is widely used in traditional Chinese medicine, has been shown to exert significant anti-inflammatory effects and improve depression-like behavior caused by inflammation.
Keywords: Magnolia officinalis; antioxidant; honokiol; neuroinflammation; neuropathic pain.
Honokiol ameliorated LPS-induced NF-κB activation in the hippocampus and significantly reduced the levels of the pro-inflammatory cytokines; tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), and interferon γ (IFN-γ). In addition, honokiol inhibited LPS-induced indoleamine 2,3-dioxygenase (IDO) activation and quinolinic acid (a toxic product) increase and reduced the level of free calcium in brain tissue, thereby inhibiting calcium overload.
Modern research has identified two biphenolic compounds, honokiol and its structural isomer magnolol, as the primary active compounds in magnolia bark. Magnolia also contains other active ingredients, including eudesmol, a triterpene compound with antioxidant properties
* The statements in this section have not been evaluated by the FDA or EFSA.
References
1. Borgonetti V, Galeotti N. Honokiol-Rich Magnolia officinalis Bark Extract Attenuates Trauma-Induced Neuropathic Pain. Antioxidants (Basel). 2023 Jul 28;12(8):1518. doi: 10.3390/antiox12081518. PMID: 37627513; PMCID: PMC10451803.
2. Zhang B, Wang PP, Hu KL, et al. Antidepressant-Like Effect and Mechanism of Action of Honokiol on the Mouse Lipopolysaccharide (LPS) Depression Model. Molecules. 2019;24(11):2035. Published 2019 May 28. doi:10.3390/molecules24112035
3. Borgonetti V, Galeotti N. Honokiol-Rich Magnolia officinalis Bark Extract Attenuates Trauma-Induced Neuropathic Pain. Antioxidants (Basel). 2023 Jul 28;12(8):1518. doi: 10.3390/antiox12081518. PMID: 37627513; PMCID: PMC10451803.
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