What is N-Acetylneuraminic acid (Neu5Ac)?
N-Acetylneuraminic acid (Neu5Ac), also known as NeuAc, is a chemical compound and the most common type of sialic acid found in human and mammalian cells. It's a negatively charged residue found in complex glycans on glycoproteins and mucins at the cell membrane, and at the ends of sugar chains on plasma membrane proteins.
Keywords: N-Acetylneuraminic acid, Sia, Physiological effects, Biosynthesis, Metabolic engineering strategies
Function:
1. Anti-virus function.
2. Anti-cancer function.
3. Anti-inflammation function.
4. Defensive function against bacteriological infectiong.
5. Controlling ability of immune system.
6. Restraining ability against pigmentation.
7. Signal transformation in nerve cells.
8. Play a key role in brain development and learning.
9. As precursor for the manufacture of many pharmaceutical drugs. |
N-Acetylneuraminic acid (NANA) is a sialic acid that has many effects on the body, including:
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Skin health
In human experiments, NANA improved skin firmness, elasticity, and the appearance of wrinkles. NANA is commonly used in skincare products and is included in the cosmetic regulations of the US and EU.
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Inflammation
NANA may prevent inflammation and oxidative stress caused by high-fat diets, hyperlipidemia, and other factors.
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Obesity
In mice fed a high-fat diet, NANA supplementation reduced body weight gain, serum lipid levels, and other markers.
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Brain health
NANA is a key component of sialic acids, which are important for brain health and detoxification.
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Immune system
NANA may help boost the immune system.
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Other effects
NANA can also inhibit melanogenesis, promote calcium ion binding, and increase the viscosity of glycoproteins. However, NANA can also trigger myocardial injury and is associated with atrial fibrillation and left atrial enlargement.
* The statements in this section have not been evaluated by the FDA or EFSA.
References
1.Wang Z, Nie X, Gao F, Tang Y, Ma Y, Zhang Y, Gao Y, Yang C, Ding J, Wang X.CNS Neurosci Ther. 2023 Nov;29(11):3183-3198. doi: 10.1111/cns.14253. Epub 2023 May 24.PMID: 37222223
2.De Meo C, Jones BT.Adv Carbohydr Chem Biochem. 2018;75:215-316. doi: 10.1016/bs.accb.2018.09.005. Epub 2018 Nov 23.PMID: 30509401
3.Han Z, Thuy-Boun PS, Pfeiffer W, Vartabedian VF, Torkamani A, Teijaro JR, Wolan DW.Sci Rep. 2021 Feb 26;11(1):4763. doi: 10.1038/s41598-021-83875-w.PMID: 33637779
4.Hwang J, Kim YR, Park JY, Nam WH, Kim J, Cho J, Kim Y.ACS Appl Mater Interfaces. 2022 Apr 13;14(14):16100-16107. doi: 10.1021/acsami.2c02922. Epub 2022 Apr 4.PMID: 35377593
5.Pang Q, Han H, Liu X, Wang Z, Liang Q, Hou J, Qi Q, Wang Q.Metab Eng. 2020 May;59:36-43. doi: 10.1016/j.ymben.2020.01.002. Epub 2020 Jan 16.PMID: 31954846
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