What is Dihydroberberine?
Dihydroberberine (DHB) is an enhanced form of berberine that includes added hydrogen. The body has difficulty absorbing regular berberine but absorbs DHB 5 to 10 times better. This means that when you take DHB, your body can use it more effectively, resulting in lower and less frequent doses.
Dihydroberberine (DHB) is emerging as a popular supplement for its enhanced bioavailability and therapeutic efficacy compared to its precursor, Berberine. Berberine, a natural compound, has been widely used for its antimicrobial and anti-inflammatory properties. It has also shown promise in improving glucose and lipid metabolism, supporting cardiovascular health, and offering neuroprotective effects.

Several studies have underscored the superiority of Dihydroberberine (DHB) over Berberine in managing health outcomes. For instance, a study titled Absorption Kinetics of Berberine and Dihydroberberine and Their Impact on Glycemia: A Randomized, Controlled, Crossover Pilot Trial investigated the bioavailability and therapeutic efficacy of Berberine compared to DHB in a cohort of five healthy adult males.
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Dihydroberberine, a derivative of berberine, offers potential benefits similar to berberine, like improved insu*lin sensitivity and blood sugar control, but with potentially better bioavailability and fewer digestive issues due to lower required dosages.
Here's a more detailed look at the potential benefits of dihydroberberine:
Metabolic Health and Insu*lin Sensitivity:
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Improved Insu*lin Sensitivity:
Dihydroberberine enhances the body's response to insu*lin, making it more effective at lowering blood sugar levels.
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Blood Sugar Control:
It can help maintain healthy blood glucose levels, potentially beneficial for individuals with insu*lin resistance or type 2 diabetes.
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Lipid Metabolism:
Dihydroberberine may support healthy cholesterol and lipid metabolism, contributing to overall cardiovascular health.
Digestive Comfort and Bioavailability:
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Lower Doses, Better Absorption:
Dihydroberberine is often more bioavailable than berberine, meaning the body can absorb and utilize it more efficiently, even at lower doses.
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Reduced Digestive Upset:
Because lower doses are effective, dihydroberberine may cause fewer digestive issues compared to berberine, which can sometimes cause stomach upset at higher doses.
Other Potential Benefits:
- Weight Management: Improved insu*lin sensitivity and blood sugar control can contribute to better weight management.
- Hormonal Balance: Dihydroberberine may support hormonal balance, potentially beneficial for conditions like PCOS.
- Gut Health: It may promote a balanced gut microbiome, contributing to overall health.
- Antioxidant and Anti-inflammatory Effects: Dihydroberberine may possess antioxidant and anti-inflammatory properties.




* The statements in this section have not been evaluated by the FDA or EFSA.
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