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Luteolin belongs to the family of flavonoids, which have anti-inflammatory functions, potentially useful in a clinical context, particularly for patients suffering from cancer, neuropsychiatric disorders, inflammatory bowel conditions. This peculiarity has been used for centuries in traditional Chinese medicine, for many different diseases.
Keywords: Flavonoids; immunology; inflammation; luteolin; microbiota. Alzheimer's disease; C6 cells; astrocyte; endoplasmic reticulum stress; luteolin; neuroinflammation.
Luteolin is a natural flavonoid compound with a variety of potential health benefits, including:
- Anti-inflammatory: Luteolin can help reduce inflammation.
- Antioxidant: Luteolin can help protect cells from damage caused by reactive oxygen species (ROS).
- Anticancer: Luteolin can help inhibit tumor cell proliferation and metastasis. It can also help reverse epithelial-to-mesenchymal transition (EMT), which is associated with cancer cell progression.
- Neuroprotective: Luteolin may help protect against neurodegenerative diseases like Parkinson's disease.
- Cardioprotective: Luteolin may have multiple cardio-protective effects.
Luteolin can suppress proinflammatory mediators (e.g., IL-1β, IL-6, IL-8, IL-17, IL-22, TNF-α and COX-2) and regulate various signaling pathway (e.g., the NF-κB, JAK-STAT as well as TLR signaling pathway). In this way, luteolin modulates many inflammatory processes of the skin
luteolin might be a promising molecule for the development of topic formulations and systemic agents against inflammatory skin diseases
| Luteolin, a polyphenolic plant flavonoid, has been attributed with numerous beneficial properties like anti-cancer, antioxidant, and anti-inflammatory action. Luteolin has been reported earlier to be neuroprotective in models of spinal cord injury and traumatic brain injury and also induces neurite outgrowth in PC12 cells. |
* The statements in this section have not been evaluated by the FDA or EFSA.
References
1. Franza, Laura et al. "Luteolin, inflammation and cancer: Special emphasis on gut microbiota." BioFactors (Oxford, England) vol. 47,2 (2021): 181-189. doi:10.1002/biof.1710
2. Kou, Jie-Jian et al. "Luteolin alleviates cognitive impairment in Alzheimer's disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation." Acta pharmacologica Sinica vol. 43,4 (2022): 840-849. doi:10.1038/s41401-021-00702-8
3. Gendrisch, Fabian et al. "Luteolin as a modulator of skin aging and inflammation." BioFactors (Oxford, England) vol. 47,2 (2021): 170-180. doi:10.1002/biof.1699
4. Wang, I-Chieh et al. "Baicalein and luteolin inhibit ischemia/reperfusion-induced ferroptosis in rat cardiomyocytes." International journal of cardiology vol. 375 (2023): 74-86. doi:10.1016/j.ijcard.2022.12.018
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